Abstract |
Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors.
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Authors | J Ishida, M Kozuka, H Wang, T Konoshima, H Tokuda, M Okuda, X Yang Mou, H Nishino, N Sakurai, K H Lee, M Nagai |
Journal | Cancer letters
(Cancer Lett)
Vol. 159
Issue 2
Pg. 135-40
(Oct 31 2000)
ISSN: 0304-3835 [Print] Ireland |
PMID | 10996724
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Carcinogens
- Diarylheptanoids
- Hydrocarbons, Cyclic
- Terpenes
- myricanone
- 9,10-Dimethyl-1,2-benzanthracene
- Tetradecanoylphorbol Acetate
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(toxicity)
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Carcinogens
(toxicity)
- Diarylheptanoids
- Dose-Response Relationship, Drug
- Female
- Herpesvirus 4, Human
(drug effects)
- Humans
- Hydrocarbons, Cyclic
(chemistry, pharmacology)
- Mice
- Mice, Inbred ICR
- Papilloma
(chemically induced, prevention & control)
- Skin Neoplasms
(chemically induced, prevention & control)
- Specific Pathogen-Free Organisms
- Terpenes
(pharmacology)
- Tetradecanoylphorbol Acetate
(pharmacology)
- Time Factors
- Tumor Cells, Cultured
- Virus Activation
(drug effects)
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