Abstract |
Diarylheptanoids possess potent anti-inflammatory properties. However, the mechanism of their action is not fully understood. In this study, we found that three diarylheptanoids, 1-(3, 5-dimethoxy-4-hydroxyphenyl)-7-phenylhept-1-en-3-one (YPE-01), yakuchinone B and demethyl- yakuchinone B, reduced the adhesion of both human monocytic cell line U937 and human eosinophilic cell line EoL-1 cells to tumor necrosis factor-alpha ( TNF-alpha)-treated human umbilical vein endothelial cells. In addition, they suppressed interleukin-1beta- or TNF-alpha-induced expression of E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on the surface of the endothelial cells. Since YPE-01 reduced both VCAM-1 and ICAM-1 mRNA induction in TNF-alpha-stimulated endothelial cells, diarylheptanoids appeared to suppress adhesion molecule expression at the transcriptional level. Furthermore, YPE-01 suppressed both VCAM-1 and ICAM-1 mRNA induction as well as edema in 12-O-tetradecanoylphorbol 13-acetate (TPA)-inflamed mice ears in vivo. These results suggest that the anti-inflammatory action of diarylheptanoids is, at least in part, due to their suppressive effect on the surface expression of inducible adhesion molecules in endothelial cells, and subsequent leukocyte adhesion.
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Authors | R Yamazaki, H Hatano, R Aiyama, T Matsuzaki, S Hashimoto, T Yokokura |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 404
Issue 3
Pg. 375-85
(Sep 22 2000)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 10996603
(Publication Type: Journal Article)
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Chemical References |
- Cell Adhesion Molecules
- Diarylheptanoids
- E-Selectin
- Tumor Necrosis Factor-alpha
- Vascular Cell Adhesion Molecule-1
- yakuchinone B
- Intercellular Adhesion Molecule-1
- Guaiacol
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Topics |
- Animals
- Cell Adhesion Molecules
(drug effects, metabolism)
- Cells, Cultured
- Diarylheptanoids
- E-Selectin
(drug effects, metabolism)
- Edema
(drug therapy, metabolism)
- Endothelium, Vascular
(drug effects, metabolism)
- Guaiacol
(analogs & derivatives, pharmacology, therapeutic use)
- Humans
- Intercellular Adhesion Molecule-1
(drug effects, metabolism)
- Male
- Mice
- Mice, Inbred ICR
- Phytotherapy
- Plants, Medicinal
(therapeutic use)
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
(pharmacology)
- Umbilical Veins
(drug effects, metabolism)
- Vascular Cell Adhesion Molecule-1
(drug effects, metabolism)
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