Vitamin D 1 alpha-hydroxylase.

Abstract	The rate-limiting, hormonally regulated step in the bioactivation of vitamin D is renal 1 alpha-hydroxylation by P450c1 alpha. In late 1997, we reported the cloning of the human cDNA and gene from keratinocytes, and established that P450c1 alpha mutations cause vitamin D-dependent rickets, type I, while three other groups reported the cloning of the rodent enzyme. The genetics of P450c1 alpha are well established, with studies of over 30 patients, but the molecular mechanisms for the hormonal regulation of P450c1 alpha are still under investigation.
Authors	W L Miller, A A Portale
Journal	Trends in endocrinology and metabolism: TEM (Trends Endocrinol Metab) Vol. 11 Issue 8 Pg. 315-9 (Oct 2000) ISSN: 1043-2760 [Print] United States
PMID	10996526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References	Steroid Hydroxylases vitamin D 1-alpha hydroxylase
Topics	Animals Gene Expression Regulation, Enzymologic Humans Steroid Hydroxylases (biosynthesis, genetics, metabolism)

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