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Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).

Abstract
An easy methodology for triterpene isolation is shown. Evaluation in rats for antiulcer activity of friedelan-3beta-ol 1 and friedelin 2. The two triterpenes isolated from the leaves of Maytenus ilicifolia, did not decrease gastric ulcers when tested on indometacine induced ulcer model in rats.
AuthorsC L Queiroga, G F Silva, P C Dias, A Possenti, J E de Carvalho
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 72 Issue 3 Pg. 465-8 (Oct 2000) ISSN: 0378-8741 [Print] Ireland
PMID10996287 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Ulcer Agents
  • Triterpenes
  • friedelan-3-ol
  • friedelin
  • Indomethacin
Topics
  • Animals
  • Anti-Ulcer Agents (chemistry, isolation & purification, pharmacology)
  • Drug Evaluation
  • Gas Chromatography-Mass Spectrometry
  • Indomethacin (adverse effects)
  • Magnetic Resonance Spectroscopy
  • Male
  • Rats
  • Rats, Wistar
  • Rosales (chemistry)
  • Stomach Ulcer (chemically induced, prevention & control)
  • Triterpenes (chemistry, isolation & purification, pharmacology)

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