Modulation of cell cycle regulatory protein expression and suppression of tumor growth by mimosine in nude mice. | CureHunter

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Modulation of cell cycle regulatory protein expression and suppression of tumor growth by mimosine in nude mice.

Abstract	Our previous results demonstrated that the plant amino acid mimosine blocked cell cycle progression and suppressed proliferation of human lung cancer cells in vitro by multiple mechanisms. Inhibition of cyclin D1 expression or induction of cyclin-dependent kinase inhibitor p21WAF1 expression was found in mimosine-treated lung cancer cells. However, whether mimosine may modulate the expression of these cell cycle regulatory proteins and suppress tumor growth in vivo is unknown. In this study, we examined the anti-cancer effect of mimosine on human H226 lung cancer cells grown in nude mice. Our results demonstrated that mimosine inhibits cyclin D1 and induces p21WAF1 expression in vivo. Furthermore, results of TUNEL analysis indicated that mimosine may induce apoptosis to suppress tumor growth in nude mice. Collectively, these results suggest that mimosine exerts anti-cancer effect in vivo and might be useful in the therapy of lung cancer.
Authors	H C Chang, C F Weng, M H Yen, L Y Chuang, W C Hung
Journal	International journal of oncology (Int J Oncol) Vol. 17 Issue 4 Pg. 659-65 (Oct 2000) ISSN: 1019-6439 [Print] Greece
PMID	10995875 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	CDKN1A protein, human Cdkn1a protein, mouse Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p21 Cyclins Cyclin D1 Mimosine
Topics	Animals Apoptosis (drug effects) Cell Cycle Proteins (biosynthesis, drug effects) Cell Division (drug effects) Cyclin D1 (biosynthesis, drug effects) Cyclin-Dependent Kinase Inhibitor p21 Cyclins (biosynthesis, drug effects) Humans Immunohistochemistry In Situ Nick-End Labeling Mice Mice, Nude Mimosine (pharmacology) Neoplasm Transplantation Neoplasms, Experimental (metabolism, pathology, prevention & control) Time Factors Transplantation, Heterologous Tumor Cells, Cultured Xenograft Model Antitumor Assays

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