| Abstract | The atherogenic oxidative modification of low-density lipoprotein is suggested to occur in the aortic intima. There is reasonable evidence to suggest that antioxidants might be beneficial in preventing or retarding the progression of atherosclerosis. Exercise, estrogens, and substitution of polyunsaturated fat for saturated fat are beneficial in the prevention of atherosclerosis. Yet, paradoxically, they are capable of inducing an oxidative stress. To reconcile with this paradox, we postulate that under certain conditions an oxidative stress might be beneficial by inducing antioxidant enzymes in arterial cells. However, those with genetic deficiency in antioxidant enzymes or those who poorly respond to oxidative stress or those with overwhelming plasma oxidative stress might need additional antioxidant protection. |
| Authors | S Parthasarathy, N Santanam, S Ramachandran, O Meilhac
(Affiliation: Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA. spartha at emory.edu)
|
| Journal | Free radical research
(Free Radic Res)
Vol. 33
Issue 3
Pg. 197-215
(Sep 2000)
ISSN: 1071-5762 SWITZERLAND |
| PMID | 10993475
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
|
| Chemical References |
- Antioxidants
- Dietary Fats, Unsaturated
- Estrogens
- Lipids
- Lipoproteins
- Lipoproteins, LDL
- oxidized low density lipoprotein
|
| Topics |
- Animals
- Antioxidants
- Arteries
(metabolism)
- Arteriosclerosis
- Dietary Fats, Unsaturated
- Estrogens
- Exercise
- Humans
- Lipids
(blood)
- Lipoproteins
(blood)
- Lipoproteins, LDL
(blood, metabolism)
- Oxidative Stress
|
