Abstract |
We compared urinary protein C inhibitor (uPCI) with low molecular weight heparin ( LMWH) in terms of the effect on the pathophysiology of disseminated intravascular coagulation ( DIC), such as hypercoagulation, induction of secondary fibrinolysis and organ failure, using lipopolysaccharide (LPS)-induced DIC in rats. The uPCI (0.5 and 1.0 mg/kg) administration significantly inhibited both the decrease in fibrinogen level and the increase in fibrin/fibrinogen degradation products ( FDP) level, and the effects compared favorably with those of LMWH (100 and 200 IU/kg). Both uPCI (0.5 and 1.0 mg/kg) and a low dose of LMWH also inhibited the increases in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), thrombin, and plasma kallikrein equally, but a high dose of LMWH did not inhibit the changes in those parameters. Furthermore, uPCI dose-dependently prevented the prolongation of activated partial thromboplastin time (APTT), while LMWH excessively prolonged APTT at a high dose. These results suggest that the preventive effect of uPCI on the pathophysiology of DIC compares favorably with that of LMWH, including the lack of a hemorrhagic reaction in contrast to LMWH.
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Authors | W Izutani, M Fujita, K Nishizawa, J Koga |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 23
Issue 9
Pg. 1046-50
(Sep 2000)
ISSN: 0918-6158 [Print] Japan |
PMID | 10993202
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fibrin Fibrinogen Degradation Products
- Heparin, Low-Molecular-Weight
- Lipopolysaccharides
- Protein C
- Fibrinogen
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Disseminated Intravascular Coagulation
(blood, drug therapy)
- Fibrin Fibrinogen Degradation Products
(analysis)
- Fibrinogen
(analysis)
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Lipopolysaccharides
(toxicity)
- Male
- Partial Thromboplastin Time
- Platelet Count
- Protein C
(antagonists & inhibitors)
- Rats
- Rats, Sprague-Dawley
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