Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I.

Deoxynybomycin was identified as an inducer of p21the/WAF1 gene following screening using a reporter, p21/luciferase. The present study examined its anti-proliferative effect on human tumor cell lines. Deoxynybomycin selectively inhibited growth of human osteoblastic sarcoma Saos-2, gastric cancer TMK-1, and monocytic leukemia THP-1 cells, but did not affect survival of normal human fibroblasts at doses up to 5 microg/ml. Results from an assay system using a panel of 39 human cancer cell lines indicated that deoxynybomycin has selective cytotoxic activity against lung carcinoma cell lines. Deoxynybomycin induced apoptosis in Saos-2, TMK-1, and THP-1 cells as revealed by DNA fragmentation and TUNEL assays. It inhibited topoisomerase I but not topoisomerase II. These results suggest that deoxynybomycin may be useful in cancer chemotherapy.
AuthorsK Egawa, T Yamori, C Nosaka, S Kunimoto, T Takeuchi, K Nos
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 23 Issue 9 Pg. 1036-40 (Sep 2000) ISSN: 0918-6158 [Print] JAPAN
PMID10993200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Enzyme Inhibitors
  • Quinolones
  • Topoisomerase I Inhibitors
  • deoxynybomycin
  • Antibiotics, Antineoplastic (pharmacology)
  • Apoptosis (drug effects)
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins (genetics)
  • Enzyme Inhibitors (pharmacology)
  • Humans
  • Promoter Regions, Genetic
  • Quinolones (pharmacology)
  • Topoisomerase I Inhibitors
  • Tumor Cells, Cultured

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