HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I.

Abstract
Deoxynybomycin was identified as an inducer of p21the/WAF1 gene following screening using a reporter, p21/luciferase. The present study examined its anti-proliferative effect on human tumor cell lines. Deoxynybomycin selectively inhibited growth of human osteoblastic sarcoma Saos-2, gastric cancer TMK-1, and monocytic leukemia THP-1 cells, but did not affect survival of normal human fibroblasts at doses up to 5 microg/ml. Results from an assay system using a panel of 39 human cancer cell lines indicated that deoxynybomycin has selective cytotoxic activity against lung carcinoma cell lines. Deoxynybomycin induced apoptosis in Saos-2, TMK-1, and THP-1 cells as revealed by DNA fragmentation and TUNEL assays. It inhibited topoisomerase I but not topoisomerase II. These results suggest that deoxynybomycin may be useful in cancer chemotherapy.
AuthorsK Egawa, T Yamori, C Nosaka, S Kunimoto, T Takeuchi, K Nos
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 23 Issue 9 Pg. 1036-40 (Sep 2000) ISSN: 0918-6158 [Print] JAPAN
PMID10993200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Enzyme Inhibitors
  • Quinolones
  • Topoisomerase I Inhibitors
  • deoxynybomycin
Topics
  • Antibiotics, Antineoplastic (pharmacology)
  • Apoptosis (drug effects)
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins (genetics)
  • Enzyme Inhibitors (pharmacology)
  • Humans
  • Promoter Regions, Genetic
  • Quinolones (pharmacology)
  • Topoisomerase I Inhibitors
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: