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In vitro activities of ravuconazole (BMS-207147) against 541 clinical isolates of Cryptococcus neoformans.

Abstract
The in vitro activities of the new triazole, ravuconazole (BMS-207147), were compared to those of fluconazole and itraconazole against 541 clinical isolates of Cryptococcus neoformans. Isolates were obtained from cerebrospinal fluid (396), blood (116), and miscellaneous clinical specimens (29). Overall, ravuconazole (MIC at which 90% of the isolates are inhibited [MIC(90)], 0.25 microg/ml) was more active than either itraconazole (MIC(90), 0.5 microg/ml) or fluconazole (MIC(90), 8 microg/ml). Among the isolates inhibited by > or =16 microg of fluconazole/ml, 90.2% were inhibited by < or =1 microg of ravuconazole/ml. On the basis of our findings and the favorable pharmacokinetic properties of ravuconazole, we suggest that ravuconazole may be useful for the treatment of infectious diseases due to C. neoformans and that further clinical studies to confirm these promising in vitro results are warranted.
AuthorsT Yamazumi, M A Pfaller, S A Messer, A Houston, R J Hollis, R N Jones
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 44 Issue 10 Pg. 2883-6 (Oct 2000) ISSN: 0066-4804 [Print] United States
PMID10991880 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Thiazoles
  • Triazoles
  • Itraconazole
  • Fluconazole
  • ER 30346
Topics
  • Antifungal Agents (pharmacology)
  • Cryptococcosis (blood, cerebrospinal fluid, microbiology)
  • Cryptococcus neoformans (drug effects)
  • Fluconazole (pharmacology)
  • Humans
  • Itraconazole (pharmacology)
  • Microbial Sensitivity Tests
  • Thiazoles (pharmacology)
  • Triazoles (pharmacology)

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