Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.

Abstract	Pretreatment of SKH-1 mice with p.o.-administered 0.6% green tea (6 mg of lyophilized tea solids/ml) or 0.044% caffeine (0.44 mg/ml; concentration present in 0.6% green tea) for 2 weeks enhanced UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the epidermis. These effects of p.o.-administered green tea or caffeine on early adaptive responses to UV provide the first demonstration of in vivo up-regulation of a tumor suppressor gene by a chemopreventive agent. The stimulatory effect of green tea and caffeine on UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells may play a role in the inhibitory effects of tea and caffeine on UV-induced carcinogenesis.
Authors	Y P Lu, Y R Lou, X H Li, J G Xie, D Brash, M T Huang, A H Conney
Journal	Cancer research (Cancer Res) Vol. 60 Issue 17 Pg. 4785-91 (Sep 01 2000) ISSN: 0008-5472 [Print] United States
PMID	10987287 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anticarcinogenic Agents Cdkn1a protein, mouse Cyclin-Dependent Kinase Inhibitor p21 Cyclins Tea Tumor Suppressor Protein p53 Caffeine DNA Bromodeoxyuridine
Topics	Adaptation, Biological (drug effects, radiation effects) Administration, Oral Animals Anticarcinogenic Agents (pharmacology) Apoptosis (drug effects, radiation effects) Bromodeoxyuridine (metabolism) Caffeine (pharmacology) Cell Division (drug effects, radiation effects) Cyclin-Dependent Kinase Inhibitor p21 Cyclins (biosynthesis, genetics) DNA (metabolism) Epidermis (drug effects, metabolism, radiation effects) Female Mice Mice, Hairless Stimulation, Chemical Sunburn (metabolism, pathology) Tea Tumor Suppressor Protein p53 (biosynthesis, genetics) Ultraviolet Rays (adverse effects)

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