Abstract | OBJECTIVE: To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions. STUDY DESIGN: RESULTS:
VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. PD-ECGF was found in the majority of lesions. CONCLUSION: Demonstration of angiogenesis may suggest which preinvasive lesions will progress to invasive cancer.
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Authors | A B MacLean, W M Reid, K J Rolfe, S J Gammell, H E Pugh, K C Gatter, A C Wong Te Fong, J C Crow, C W Perrett |
Journal | The Journal of reproductive medicine
(J Reprod Med)
Vol. 45
Issue 8
Pg. 609-12
(Aug 2000)
ISSN: 0024-7758 [Print] United States |
PMID | 10986676
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelial Growth Factors
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Thymidine Phosphorylase
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Topics |
- Carcinoma in Situ
(metabolism, pathology)
- Endothelial Growth Factors
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Lichen Sclerosus et Atrophicus
(metabolism, pathology)
- Lymphokines
(metabolism)
- Neovascularization, Pathologic
- Precancerous Conditions
(metabolism, pathology)
- Thymidine Phosphorylase
(metabolism)
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Vulvar Diseases
(metabolism, pathology)
- Vulvar Neoplasms
(metabolism, pathology)
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