Abstract | BACKGROUND:
Methotrexate (MTX) is a very effective chemotherapeutic drug, widely used in various malignant diseases for systemic therapy. In some cases, MTX-induced renal failure occurs which may not be prevented by the standard agent folin acid as a specific antidot. This results in a MTX-accumulation in the body tissue with subsequent massive toxic side effects. CASE REPORT: We report on a 62-year-old woman with acute lymphoblastic leukemia (first diagnosis November 1997) receiving chemotherapy with 2,340 mg methotrexate over 24 hours. After an increase of the MTX-plasma-level 36 hours following MTX-application, increased serum creatinine levels (maximum 5.07 mg/dl) were found. The application of folinic acid was without any significant effect. Fifty-six hours following MTX, 50 U/kg carboxypeptidase-G2 was infused. The MTX-plasma-level decreased rapidly and a recovery of renal function was monitored. CONCLUSION: CPDG2 may be highly effective in patients after development of an MTX-induced renal failure and delayed MTX-excretion.
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Authors | A von Poblozki, W Dempke, H J Schmoll |
Journal | Medizinische Klinik (Munich, Germany : 1983)
(Med Klin (Munich))
Vol. 95
Issue 8
Pg. 457-60
(Aug 15 2000)
ISSN: 0723-5003 [Print] Germany |
Vernacular Title | Carboxypeptidase-G2-Rescue bei einer Patientin mit Methotrexat-induziertem Nierenversagen. |
PMID | 10985069
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Creatinine
- gamma-Glutamyl Hydrolase
- Methotrexate
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Topics |
- Acute Kidney Injury
(blood, chemically induced, drug therapy)
- Antimetabolites, Antineoplastic
(adverse effects, blood)
- Creatinine
(blood)
- Female
- Humans
- Infusions, Intravenous
- Methotrexate
(adverse effects, blood)
- Middle Aged
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(complications, drug therapy)
- Treatment Outcome
- gamma-Glutamyl Hydrolase
(administration & dosage, therapeutic use)
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