Abstract |
Because concurrent infections with geohelminth parasites might impair the immune response to oral vaccines, we studied the vibriocidal antibody response to the oral cholera vaccine CVD 103-HgR in children infected with Ascaris lumbricoides and investigated the effect of albendazole pretreatment on the postvaccination response. Children with ascariasis were randomized to receive either 2 sequential doses of 400 mg of albendazole or placebo. After the second dose, CVD 103-HgR was given, and serum vibriocidal antibody levels were measured before and 10 days after vaccination. Postvaccination rates of seroconversion were greater in the treatment group that received albendazole (P=.06). Significantly greater rates of seroconversion and geometric mean titer were observed in the albendazole group in subjects with non-O ABO blood groups. A significant association was observed between vibriocidal seroconversion rates and treatment group, suggesting that A. lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups.
|
Authors | P J Cooper, M E Chico, G Losonsky, C Sandoval, I Espinel, R Sridhara, M Aguilar, A Guevara, R H Guderian, M M Levine, G E Griffin, T B Nutman |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 182
Issue 4
Pg. 1199-206
(Oct 2000)
ISSN: 0022-1899 [Print] United States |
PMID | 10979918
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Anthelmintics
- Antibodies, Bacterial
- Bacterial Vaccines
- Blood Group Antigens
- Cholera Vaccines
- Vaccines, Attenuated
- cholera vaccine CVD 103-HgR
- Albendazole
|
Topics |
- Adolescent
- Albendazole
(therapeutic use)
- Animals
- Anthelmintics
(therapeutic use)
- Antibodies, Bacterial
(blood)
- Antibody Formation
- Ascariasis
(drug therapy, immunology)
- Ascaris lumbricoides
(drug effects)
- Bacterial Vaccines
(immunology)
- Blood Group Antigens
(immunology)
- Child
- Cholera Vaccines
(immunology)
- Drug Interactions
- Ecuador
- Female
- Humans
- Male
- Trichuris
(drug effects)
- Vaccines, Attenuated
(immunology)
|