HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR.

Abstract
Because concurrent infections with geohelminth parasites might impair the immune response to oral vaccines, we studied the vibriocidal antibody response to the oral cholera vaccine CVD 103-HgR in children infected with Ascaris lumbricoides and investigated the effect of albendazole pretreatment on the postvaccination response. Children with ascariasis were randomized to receive either 2 sequential doses of 400 mg of albendazole or placebo. After the second dose, CVD 103-HgR was given, and serum vibriocidal antibody levels were measured before and 10 days after vaccination. Postvaccination rates of seroconversion were greater in the treatment group that received albendazole (P=.06). Significantly greater rates of seroconversion and geometric mean titer were observed in the albendazole group in subjects with non-O ABO blood groups. A significant association was observed between vibriocidal seroconversion rates and treatment group, suggesting that A. lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups.
AuthorsP J Cooper, M E Chico, G Losonsky, C Sandoval, I Espinel, R Sridhara, M Aguilar, A Guevara, R H Guderian, M M Levine, G E Griffin, T B Nutman
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 182 Issue 4 Pg. 1199-206 (Oct 2000) ISSN: 0022-1899 [Print] United States
PMID10979918 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Anthelmintics
  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Blood Group Antigens
  • Cholera Vaccines
  • Vaccines, Attenuated
  • cholera vaccine CVD 103-HgR
  • Albendazole
Topics
  • Adolescent
  • Albendazole (therapeutic use)
  • Animals
  • Anthelmintics (therapeutic use)
  • Antibodies, Bacterial (blood)
  • Antibody Formation
  • Ascariasis (drug therapy, immunology)
  • Ascaris lumbricoides (drug effects)
  • Bacterial Vaccines (immunology)
  • Blood Group Antigens (immunology)
  • Child
  • Cholera Vaccines (immunology)
  • Drug Interactions
  • Ecuador
  • Female
  • Humans
  • Male
  • Trichuris (drug effects)
  • Vaccines, Attenuated (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: