Experimental models of Reye's syndrome.

Abstract

Intraperitoneal administration of 4-pentenoic acid (20 mg/kg/day for seven days or ten doses of 50 mg/kg with 4 h intervals) or acetylsalicylic acid (50 mg/kg 1 hour after single pyrogenal injection) to rats reproduced metabolic disorders characteristic of Reye's syndrome: hyperenzymemia, hyperbilirubinemia, decreased levels of ketone bodies and urea, hypoglycemia, hypoproteinemia, accumulation of ammonia and phenol, and acidosis. Necroses and microvesicular steatosis were found in the liver.

• Authors: A S Saratikov, A I Vengerovskii, A G Arbuzov, V S Chuchalin, M B Chervyakova, I V Sukhodolo
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 129 Issue 4 Pg. 400-2 (Apr 2000) ISSN: 0007-4888 [Print] United States
• PMID: 10977933 (Publication Type: Journal Article)

Topics

• Animals
• Disease Models, Animal
• Rats
• Reye Syndrome