Abstract | AIMS: METHODS: Four groups were selected: group A, 100 Black Type 1 DM patients (age at onset < 35 years, body mass index (BMI) < 27 kg/m2 and insulin dependent within 1 year of presentation); group B, 80 Black Type 2 DM patients (age at onset > 35 years, BMI > 27 kg/m2 and controlled on oral hypoglycaemic agents for at least 1 year after presentation); group C, 10 patients of varying ethnicity with DM or impaired glucose tolerance secondary to chronic pancreatitis; group D, five patients of varying ethnicity with DM associated with total lipodystrophy. Fifty healthy Black control subjects were also studied (group E). Serum GAD-AB and random C-peptide levels were measured by radioimmunoassay. RESULTS: Mean C-peptide concentration was significantly lower in Type 1 DM patients than Type 2 DM patients (P < 0.00001). Forty-four patients with Type 1 DM were GAD-AB-positive compared to two patients with Type 2 DM. Two control subjects were also GAD-AB-positive. No patient in the other groups had a titre > 1 U/ml. Type 1 DM patients who were GAD-AB-positive did not differ from those who were GAD-AB-negative for age at onset, duration of DM or C-peptide concentrations. CONCLUSIONS: Auto-immune beta-cell destruction has an important role in the pathogenesis of Type 1 DM amongst African patients. However, Type 2 African DM patients and other diabetes subtypes are largely GAD-AB-negative.
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Authors | V R Panz, W J Kalk, M Zouvanis, B I Joffe |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 17
Issue 7
Pg. 524-7
(Jul 2000)
ISSN: 0742-3071 [Print] England |
PMID | 10972582
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- C-Peptide
- Glutamate Decarboxylase
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Topics |
- Adult
- Autoantibodies
(immunology)
- Black People
- C-Peptide
(blood)
- Diabetes Mellitus
(blood, classification, immunology)
- Diabetes Mellitus, Type 1
(blood, immunology)
- Diabetes Mellitus, Type 2
(blood, immunology)
- Female
- Glutamate Decarboxylase
(immunology)
- Humans
- Male
- Middle Aged
- Pancreatic Diseases
(blood, immunology)
- Radioimmunoassay
- South Africa
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