[New data on the development of complications during epidemiological parotitis in children].

Abstract

The main factors in the pathogenesis of complicated parotitis virus infection are increased virus reproduction in the salivary gland, inhibited by the production of alpha-interferon at early stages of the infectious process. Entry of the virus into the CNS is caused by slight penetration of antiparotitis antibodies through the blood-brain barrier and by poor formation of specific immune complexes at the site of primary virus reproduction and in the liquor. Interferon therapy of patients with parotitis virus infection corrects the chain of processes in the pathogenesis. In parotitic meningitis neovir stimulates gamma-interferon, which blocks the synthesis of parotitis antigen in the cell and stimulates (through antibody stimulation) the formation of specific immune complexes released with the saliva in the gland. Viferon is more active in parotitic orchitis due to prolongation of alpha-interferon activity.

• Authors: O A Aksenov, O V Parkhaeva, A N Sizemov, N V Skripchenko, M K Bekhtereva
• Journal: Voprosy virusologii (Vopr Virusol) 2000 Jul-Aug Vol. 45 Issue 4 Pg. 24-8 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Novoe v patogeneze razvitiia oslozhneniĭ pri épidemicheskom parotite u deteĭ.
• PMID: 10971962 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Interferon-alpha
• Interferon-gamma

Topics

• Antibodies, Viral (blood)
• Child
• Humans
• Interferon-alpha (blood)
• Interferon-gamma (blood)
• Meningitis (etiology)
• Mumps (complications, therapy, virology)
• Rubulavirus (immunology)