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The use of ivermectin in controlling an outbreak of scabies in a prison.

AbstractBACKGROUND:
Ivermectin is a potentially useful treatment for scabies.
OBJECTIVES:
We aimed to evaluate the efficacy of ivermectin in the treatment of scabies in an institutional environment.
METHODS:
A single dose of ivermectin 150 microg kg-1 was given under supervision to 1153 prisoners in a prison in northern Tanzania where there was an outbreak of scabies.
RESULTS:
Thirty per cent of the prisoners were cured after 1 week, 88% after 4 weeks and 95.5% after 8 weeks. Of 16 prisoners with crusted scabies, seven (44%) still had scabies after 8 weeks. Those who were not cured were then treated with 1% lindane lotion topically, as were the prison staff who had scabies. This regimen eradicated scabies from the prison for the next 2 years.
CONCLUSIONS:
Ivermectin is an effective and safe treatment for scabies, particularly in a closed community, such as a prison, where it is easy to administer and avoids problems with compliance. It was of limited efficiency in crusted scabies as a single dose and we recommend that for such patients oral ivermectin is used in combination with a topical scabicide.
AuthorsB Leppard, A E Naburi
JournalThe British journal of dermatology (Br J Dermatol) Vol. 143 Issue 3 Pg. 520-3 (Sep 2000) ISSN: 0007-0963 [Print] England
PMID10971323 (Publication Type: Journal Article)
Chemical References
  • Antiprotozoal Agents
  • Insecticides
  • Hexachlorocyclohexane
  • Ivermectin
Topics
  • Adolescent
  • Adult
  • Aged
  • Antiprotozoal Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Disease Outbreaks
  • Drug Therapy, Combination
  • Female
  • Hexachlorocyclohexane (therapeutic use)
  • Humans
  • Infant
  • Insecticides (therapeutic use)
  • Ivermectin (therapeutic use)
  • Male
  • Middle Aged
  • Prisons
  • Scabies (drug therapy, epidemiology)
  • Tanzania (epidemiology)
  • Treatment Outcome

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