[Failure of bone marrow autograft in metastatic malignant adrenalcortical carcinoma].

Abstract

BACKGROUND:

Despite different therapeutic modalities (surgery, hormones therapy, chemotherapy), 5-year survival in patients with malignant adrenocortical carcinoma remains only 10% to 20%. Bone marrow grafts may be proposed to intensify treatment.

CASE REPORT:

In a 29-year-old patient with adrenocortical carcinoma with metastases to the lung and bone, an adjuvant bone marrow graft using peripheral stem cells was unsuccessful. Recurrence was observed at 3 months and overall survival was 2 years.

DISCUSSION:

Our case illustrates the feasibility of this approach but also emphasizes the relatively poor results obtains with only 2 years survival (1 year after the bone marrow graft), comparable with other classical modalities reported in the literature.

• Authors: E Andrès, J E Kurtz, B Lioure, P Quetin, F Maloisel, J L Schlienger, P Dufour
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 61 Issue 3 Pg. 192-3 (Sep 2000) ISSN: 0003-4266 [Print] France
• Vernacular Title: Echec de l'autogreffe de moelle osseuse dans le cortico-surrénalome malin métastatique.
• PMID: 10970942 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adrenal Cortex Neoplasms (drug therapy, radiotherapy, surgery)
• Adult
• Bone Neoplasms (secondary)
• Carcinoma (drug therapy, radiotherapy, surgery)
• Fatal Outcome
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Lung Neoplasms (secondary)
• Neoplasm Metastasis
• Transplantation, Autologous
• Treatment Failure