Thymoma with pemphigus foliaceus.

Abstract	A 75-year-old Japanese woman was referred to us because of an anterior mediastinal mass. Crusts and shallow erosions developed 10 months earlier on her upper chest, back, and scalp. Pemphigus foliaceus was diagnosed based on histological examination of skin biopsy specimens and positivity for serum anti-desmoglein 1 antibody by enzyme-linked immunosorbent assay. Neurological examination and electromyography ruled out myasthenia gravis. Total thymectomy was performed, and the postoperative pathology studies showed mixed lymphoepithelial thymoma. One year after the resection, the eruption and alopecia improved and the serum anti-desmoglein 1 antibody titer decreased, suggesting a beneficial effect of thymectomy on thymoma-related pemphigus.
Authors	K Takeshita, M Amano, T Shimizu, Y Oyamada, T Abiko, K Kobayashi, Y Futei, M Amagai, S Kuramochi, K Asano, K Yamaguchi
Journal	Internal medicine (Tokyo, Japan) (Intern Med) Vol. 39 Issue 9 Pg. 742-7 (Sep 2000) ISSN: 0918-2918 [Print] Japan
PMID	10969907 (Publication Type: Case Reports, Journal Article, Review)
Chemical References	Cytoskeletal Proteins Desmogleins Desmoplakins
Topics	Aged Biopsy Cytoskeletal Proteins (blood) Desmogleins Desmoplakins Enzyme-Linked Immunosorbent Assay Female Humans Magnetic Resonance Imaging Pemphigus (complications, pathology, surgery) Radiography, Thoracic Thymectomy Thymoma (complications, diagnosis, surgery) Thymus Neoplasms (complications, diagnosis, surgery) Tomography, X-Ray Computed

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