Abstract |
In the present study the efficacy of OST-6 ( OsteoCare), a herbomineral preparation, on bone mineralization in experimental rickets has been evaluated. This was accomplished by feeding pregnant rats and subsequently their pups with vitamin D and calcium deficient (VDCD) with low phosphorus diet. The parameters such as serum and bone mineral contents ( calcium and inorganic phosphorus), serum alkaline phosphatase, sex hormones and histology of bone were considered. VDCD resulted in a significant reduction in bone and serum calcium and inorganic phosphorus, increased serum alkaline phosphatase and decreased sex hormones ( testosterone in males, progesterone and oestrogen in females). Histologically the bone showed osteodystrophic changes and disproportionate cartilaginous proliferations in the epiphyseal region. Incorporation of OST-6 into feed at 5% concentration resulted in a complete reversal of rickets, which was substantiated by biochemical and histological observations. It has been concluded that OST-6 is useful in the management of rickets in a natural way through herbal resources.
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Authors | S K Mitra, P R Rangesh, M V Venkataranganna, U V Udupa, S Gopumadhavan, S J Seshadri |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 7
Issue 4
Pg. 265-72
(Jul 2000)
ISSN: 0944-7113 [Print] Germany |
PMID | 10969719
(Publication Type: Journal Article)
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Chemical References |
- OST-6 preparation
- Plant Extracts
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Topics |
- Animals
- Animals, Newborn
- Calcification, Physiologic
(drug effects)
- Disease Models, Animal
- Female
- Male
- Plant Extracts
(pharmacology, therapeutic use)
- Plants, Medicinal
- Pregnancy
- Random Allocation
- Rats
- Rickets
(prevention & control)
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