A case of mixed connective tissue disease (MCTD) complicated with MPO-ANCA-related necrotizing glomerulonephritis.

Abstract

Renal diseases of mixed connective tissue disease (MCTD) are not unusual. Although most of them are SLE-like renal impairment with immune complex deposits, systemic sclerosis- (SSc) like renal impairments with intimal thickening of interlobular arteries or arterioles are also encountered. Several cases of SSc complicated with MPO-ANCA-related necrotizing glomerulonephritis (nGN) are reported. Here we report a case which developed MPO-ANCA-related nGN 16 years after the diagnosis of MCTD. She exhibited pauci-immune focal nGN and significantly high titer of MPO-ANCA. She was successfully treated with prednisolone and cyclophosphamide. We believe this is the first case in which MPO-ANCA-related nGN was demonstrated in a patient with MCTD.

• Authors: N Makita, H Katori, F Takemoto, M Yokota, Y Kitamura, Y Ubara, S Hara, A Yamada
• Journal: Clinical nephrology (Clin Nephrol) Vol. 54 Issue 2 Pg. 164-8 (Aug 2000) ISSN: 0301-0430 [Print] Germany
• PMID: 10968696 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Peroxidase

Topics

• Antibodies, Antineutrophil Cytoplasmic (immunology)
• Female
• Glomerulonephritis (complications, immunology, pathology)
• Humans
• Kidney Glomerulus (pathology)
• Middle Aged
• Mixed Connective Tissue Disease (complications, immunology)
• Peroxidase (immunology)