Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines.

Abstract

5-(2-Phenyl-3'-indolal)-2-thiohydantoin (PIT) has been evaluated as an anti-cancer compound on several cancer lines organised in to subpanels representing leukemia, melanoma, and cancer of lung, colon, kidney, ovary, breast, prostate and central nervous system by the National Cancer Institute (NCI) anti-cancer drug screen programme. The compound showed inhibitory activity on several cancer cell lines. No information is available on anti-cancer potency of this compound with normal cell lines.

• Authors: S Suzen, E Buyukbingol
• Journal: Farmaco (Societa chimica italiana : 1989) (Farmaco) Vol. 55 Issue 4 Pg. 246-8 (Apr 2000) ISSN: 0014-827X [Print] France
• PMID: 10966154 (Publication Type: Journal Article)

Chemical References

• 5-(2-phenyl-3'-indolal)-2-thiohydantoin
• Antineoplastic Agents
• Phenylthiohydantoin

Topics

• Antineoplastic Agents (pharmacology)
• Cell Division (drug effects)
• Cell Survival (drug effects)
• Humans
• Phenylthiohydantoin (analogs & derivatives, chemistry, pharmacology)
• Tumor Cells, Cultured