[Effects of an herbal crataegus-camphor combination on the symptoms of cardiovascular diseases].

One hundred and ninety (190) patients presenting with "functional cardiovascular disorders" (ICD 10, F 45.3) received purely herbal combination therapy comprising crataegus and camphor (Korodin Herz-Kreislauf-Tropfen) or a placebo, identical in colour and taste to the active treatment, over a period of four weeks within the scope of a multi-centre, placebo-controlled, double-blind study. The principal criterion was the fall in the overall score obtained for a heart-related symptom complex (HSK) during administration of the herbal combination or randomly allocated placebo. The overall score fell significantly by 5.5 or 4.5 points, respectively, from a baseline value of 10.0 points each (p = 0.0165). The sub-score for exhaustion, joint pain, heart disorders, pain on pressure and the total score on the Giessen discomfort chart (GBB) indicated better efficacy with the crataegus-camphor combination than with the placebo. On completion of treatment, the investigators assessed the efficacy of the active drug as "very good to good" in 70.5% of their patients compared with a similar evaluation in just 49.5% of the placebo patients. The degree of satisfaction with the drug therapy according to physician and patient reflected the objective results obtained. 71.6% of subjects in the active drug group were satisfied with their treatment compared with just 52.7% in the placebo group. Adverse events (undesirable side effects) were recorded in 8.3% and 8.5% of patients, respectively. A correlation with the active drug therapy was established in only two cases. Tolerance was therefore positively assessed.
AuthorsU Schmidt, M Albrecht, S Schmidt
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 50 Issue 7 Pg. 613-9 (Jul 2000) ISSN: 0004-4172 [Print] GERMANY
Vernacular TitleEffekte einer pflanzlichen Crataegus-Campher-Kombination auf die Symptomatik funktioneller Herz-Kreislauf-Störungen.
PMID10965417 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Plant Extracts
  • Camphor
  • Adult
  • Camphor (therapeutic use)
  • Cardiovascular Diseases (drug therapy, physiopathology)
  • Chest Pain (drug therapy)
  • Double-Blind Method
  • Electrocardiography (drug effects)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Plant Extracts (therapeutic use)
  • Rosales (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: