Thalamic and hypothalamic tumors of childhood: endocrine late effects.

Abstract

Children who have received chemotherapy and radiation therapy for treatment of thalamic/hypothalamic tumors are at risk for late effects, specifically endocrine dysfunction. Evaluation of growth and pubertal development, thyroid function and integrity of the hypothalamic-pituitary-adrenal axis should be undertaken in a prospective manner. Issues of metabolic disturbances such as obesity, altered body composition/bone density as well as ultimate fertility also need to be addressed by ongoing prospective evaluations.

• Authors: S E Oberfield, J H Garvin Jr
• Journal: Pediatric neurosurgery (Pediatr Neurosurg) Vol. 32 Issue 5 Pg. 264-71 (May 2000) ISSN: 1016-2291 [Print] Switzerland
• PMID: 10965274 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright 2000 S. Karger AG, Basel.

Chemical References

• Growth Hormone

Topics

• Adolescent
• Adrenal Insufficiency (etiology)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Body Height (radiation effects)
• Child
• Child, Preschool
• Dose-Response Relationship, Radiation
• Endocrine System Diseases (etiology)
• Female
• Growth Disorders (etiology)
• Growth Hormone (deficiency)
• Hormone Replacement Therapy
• Humans
• Hyperlipidemias (etiology)
• Hypothalamic Neoplasms (drug therapy, radiotherapy)
• Hypothyroidism (etiology)
• Infant
• Male
• Puberty, Precocious (etiology)
• Radiation Injuries (etiology)
• Radiotherapy, Adjuvant (adverse effects)
• Supratentorial Neoplasms (complications, drug therapy, radiotherapy)