Abstract |
A population-based case-control study was designed for the investigation of any association between serum micronutrient levels and oral leukoplakia. Out of a total of 9536 subjects over the age of 40 years who participated in the oral mucosal screening programme in Tokoname city, 48 cases detected with oral leukoplakia (38 male:10 female) were recruited. For each case, four controls matched by age and sex were selected from the same cohort. We examined the fasting serum levels of retinol, alpha-tocopherol, zeaxanthin and lutein, cryptoxanthin, lycopene and carotenoids ( alpha-carotene and beta-carotene) by high-performance liquid chromatography. Among males with leukoplakia mean serum lycopene and beta-carotene levels (0.175+/-0.202, 0.357+/-0.295 micromol/l) were significantly lower than those of controls (0.257+/-0.252, 0.555+/-0.408 micromol/l) (P<0.05, P<0.005). Logistic regression analysis with leukoplakia as the dependent variable showed that high serum levels of beta-carotene were related to low risk of oral leukoplakia (odds ratio 0.160, 95% C.I.: 0.029-0.866, P<0.05). There were no significant differences in any of the serum nutrients estimated in female subjects. Our results suggest for the first time that high serum levels of beta-carotene may provide protection against oral precancer for the Japanese male.
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Authors | T Nagao, N Ikeda, S Warnakulasuriya, H Fukano, H Yuasa, M Yano, H Miyazaki, Y Ito |
Journal | Oral oncology
(Oral Oncol)
Vol. 36
Issue 5
Pg. 466-70
(Sep 2000)
ISSN: 1368-8375 [Print] England |
PMID | 10964055
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- beta Carotene
- Vitamin A
- Vitamin E
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Topics |
- Adult
- Analysis of Variance
- Antioxidants
(therapeutic use)
- Case-Control Studies
- Female
- Humans
- Japan
- Leukoplakia, Oral
(blood)
- Logistic Models
- Male
- Mouth Neoplasms
(blood)
- Smoking
(adverse effects)
- Vitamin A
(blood, therapeutic use)
- Vitamin E
(blood, therapeutic use)
- beta Carotene
(blood, therapeutic use)
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