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Serum antioxidant micronutrients and the risk of oral leukoplakia among Japanese.

Abstract
A population-based case-control study was designed for the investigation of any association between serum micronutrient levels and oral leukoplakia. Out of a total of 9536 subjects over the age of 40 years who participated in the oral mucosal screening programme in Tokoname city, 48 cases detected with oral leukoplakia (38 male:10 female) were recruited. For each case, four controls matched by age and sex were selected from the same cohort. We examined the fasting serum levels of retinol, alpha-tocopherol, zeaxanthin and lutein, cryptoxanthin, lycopene and carotenoids (alpha-carotene and beta-carotene) by high-performance liquid chromatography. Among males with leukoplakia mean serum lycopene and beta-carotene levels (0.175+/-0.202, 0.357+/-0.295 micromol/l) were significantly lower than those of controls (0.257+/-0.252, 0.555+/-0.408 micromol/l) (P<0.05, P<0.005). Logistic regression analysis with leukoplakia as the dependent variable showed that high serum levels of beta-carotene were related to low risk of oral leukoplakia (odds ratio 0.160, 95% C.I.: 0.029-0.866, P<0.05). There were no significant differences in any of the serum nutrients estimated in female subjects. Our results suggest for the first time that high serum levels of beta-carotene may provide protection against oral precancer for the Japanese male.
AuthorsT Nagao, N Ikeda, S Warnakulasuriya, H Fukano, H Yuasa, M Yano, H Miyazaki, Y Ito
JournalOral oncology (Oral Oncol) Vol. 36 Issue 5 Pg. 466-70 (Sep 2000) ISSN: 1368-8375 [Print] England
PMID10964055 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • beta Carotene
  • Vitamin A
  • Vitamin E
Topics
  • Adult
  • Analysis of Variance
  • Antioxidants (therapeutic use)
  • Case-Control Studies
  • Female
  • Humans
  • Japan
  • Leukoplakia, Oral (blood)
  • Logistic Models
  • Male
  • Mouth Neoplasms (blood)
  • Smoking (adverse effects)
  • Vitamin A (blood, therapeutic use)
  • Vitamin E (blood, therapeutic use)
  • beta Carotene (blood, therapeutic use)

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