Abstract | OBJECTIVE: METHODS: Twelve-month-old Eker rats were randomized into five treatment arms including tamoxifen, placebo, LY 326315, vehicle, and no treatment. Additional animals received ovariectomy or sham surgery at 4 months of age to determine the effect of ovarian ablation on tumor development. The study was terminated after 2 to 4 months of treatment, and tumor incidence, size, proliferative and apoptotic indices were determined. Size and incidence data were subjected to chi-square analysis. One-way analysis of variance and Fisher's least significant difference tests were used to compare proliferative and apoptotic indices. RESULTS: CONCLUSION:
SERMs have been shown to be therapeutically efficacious against breast cancer and to reduce tumor incidence in women at increased risk for this disease. The present data indicate that therapeutic efficacy may also be extended to uterine leiomyoma and demonstrate the utility of this animal model for preclinical studies to identify new therapeutic modalities.
|
Authors | C L Walker, K D Burroughs, B Davis, K Sowell, J I Everitt, R Fuchs-Young |
Journal | Journal of the Society for Gynecologic Investigation
(J Soc Gynecol Investig)
2000 Jul-Aug
Vol. 7
Issue 4
Pg. 249-56
ISSN: 1071-5576 [Print] United States |
PMID | 10964025
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Estrogen Antagonists
- Placebos
- Selective Estrogen Receptor Modulators
- Tamoxifen
- Raloxifene Hydrochloride
|
Topics |
- Animals
- Apoptosis
- Cell Division
- Disease Models, Animal
- Estrogen Antagonists
(pharmacology)
- Female
- Humans
- In Situ Nick-End Labeling
- Leiomyoma
(drug therapy, pathology)
- Ovariectomy
- Placebos
- Raloxifene Hydrochloride
(therapeutic use)
- Rats
- Rats, Mutant Strains
- Selective Estrogen Receptor Modulators
(therapeutic use)
- Tamoxifen
(therapeutic use)
- Uterine Neoplasms
(drug therapy, pathology)
|