Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type.

Abstract

PURPOSE:

A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy.

METHODS:

After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed.

RESULTS:

VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living.

CONCLUSIONS:

VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.

• Authors: B Smith, R Shatz, K Elisevich, I N Bespalova, M Burmeister
• Journal: Epilepsia (Epilepsia) Vol. 41 Issue 8 Pg. 1046-8 (Aug 2000) ISSN: 0013-9580 [Print] United States
• PMID: 10961635 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants

Topics

• Adult
• Anticonvulsants (therapeutic use)
• Cerebellum (physiopathology)
• Electric Stimulation Therapy
• Female
• Humans
• Treatment Outcome
• Unverricht-Lundborg Syndrome (drug therapy, physiopathology, therapy)
• Vagus Nerve (physiology)