Fluconazole for the prevention and treatment of tinea gladiatorum.

Abstract

BACKGROUND:

Tinea gladiatorum is a common problem in competitive wrestling. It impacts on a wrestler's ability to compete. Several methods have been advocated to prevent these infections; however, no well-designed study of pharmacologic prophylaxis has been conducted.

METHODS:

In a double blind placebo-controlled trial during the 1998 to 1999 regular wrestling season, wrestlers were randomized to receive 100 mg of fluconazole once weekly or placebo once weekly. Those not involved in the study were treated as a second control group. The effects of prophylaxis were also examined by assessing treatment of clinical infections with fluconazole 200 mg weekly for 4 weeks.

RESULTS:

There was a significantly smaller incidence of infection in those given fluconazole (6%) than in those receiving placebo (22%) and those not involved in the prophylaxis phase (18%) (P<0.05). There was also a significant reduction in the total number of infections in the fluconazole group (P<0.05). Prophylaxis with fluconazole did not impact on the severity of disease, if contracted, when compared with the placebo prophylaxis participants who contracted tinea corporis. Of 21 wrestlers with tinea infections and positive cultures, 14 were able to have their isolates identified as Trichophyton tonsurans.

CONCLUSIONS:

Fluconazole is effective and safe for primary prevention of tinea gladiatorum. We must now define when and in what population prophylaxis would be warranted.

• Authors: T D Kohl, D C Martin, R Nemeth, T Hill, D Evans
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 19 Issue 8 Pg. 717-22 (Aug 2000) ISSN: 0891-3668 [Print] United States
• PMID: 10959739 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Fluconazole

Topics

• Adolescent
• Antifungal Agents (administration & dosage)
• Double-Blind Method
• Fluconazole (administration & dosage)
• Humans
• Incidence
• Male
• Primary Prevention (methods)
• Probability
• Reference Values
• Risk Factors
• Tinea (drug therapy, epidemiology, prevention & control)
• Treatment Outcome
• Wrestling