Abstract | BACKGROUND: METHODS AND RESULTS: Into statistical analysis of the treatment effectiveness 187 persons (115 males, 72 females) were included. Other characteristics of the studied group (mean +/- SD): age 54.0 +/- 10.7 years, stature 172.0 +/- 8.7 cm, weight, BMI 28.0 +/- 3.1. Prevalence of risk factors and clinical manifestations of the atherosclerosis: ICHS 18.2%, myocardial infarction 7.5%, ICHDK 4.3%, CMP 5.3%, smoking 27.8%, arterial hypertension 63.6%, diabetes mellitus 17.6%, positive family history in ICHS 50.3%. 44.9% persons had been treated with hypolipidemics. Basic parameters of the lipid metabolism, cholesterol, LDL and HDL cholesterol and triglycerides were studied. Plasma levels of uric acid, fibrinogen, glucose and other biochemical parameters were also used to monitor the safeness of the treatment. Cholesterol concentration (7.05 +/- 0.91 mmol/l) decreased (6.14 +/- 0.89 mmol/l) almost by 15%. Triglyceride concentration decrease (from 4.43 +/- 1.84 mmol/l to 2.64 +/- 1.34 mmol/l) was more intensive (41%). HDL-cholesterol increased by almost 15%, while LDL-cholesterol decreased by 12%. Statistically significantly decreased level of the uric acid (12%), fibrinogene decrease (8.4%) reached only marginal significance. Treatment was well tolerated, only in one patient it was necessary to cut it prematurely. CONCLUSIONS:
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Authors | R Ceska, T Stulc |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 139
Issue 12
Pg. 369-73
(Jun 21 2000)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Fenofibrate 250 SR Pharmavit u nemocných se smísenou hyperlipoproteinémií. Výsledky sledování u 189 nemocných ze 13 center v CR. |
PMID | 10953407
(Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypolipidemic Agents
- Lipids
- Fenofibrate
|
Topics |
- Female
- Fenofibrate
(adverse effects, therapeutic use)
- Humans
- Hyperlipoproteinemias
(blood, drug therapy)
- Hypolipidemic Agents
(adverse effects, therapeutic use)
- Lipids
(blood)
- Male
- Middle Aged
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