Effect of coumarins on HL-60 cell differentiation.

Abstract

Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, nordalbergin, 6,7-dihydroxy-4-methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage. The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.

• Authors: S Kawaii, Y Tomono, E Katase, K Ogawa, M Yano
• Journal: Anticancer research (Anticancer Res) 2000 Jul-Aug Vol. 20 Issue 4 Pg. 2505-12 ISSN: 0250-7005 [Print] Greece
• PMID: 10953319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coumarins

Topics

• Cell Differentiation (drug effects)
• Coumarins (pharmacology)
• Dose-Response Relationship, Drug
• HL-60 Cells (drug effects)
• Humans
• Structure-Activity Relationship