Abstract |
We investigated the selective uptake of liposomes chemically modified by polysaccharides- cholesterol derivatives with 1-aminolactose ( lactose) in two human hepatoma cell lines (HUH7 and Alexander), a human colon cancer cell line (FCC) and a human lung cancer cell line (KNS). The uptakes of the labeled liposomes alone (conventional liposomes), those with cholesterol pullulan (CHP) and with lactose ( lactose CHP) were compared in four cancer cells and normal rat hepatocytes after 3 hours of incubation. The radioactivities of the lactose CHP were 4.4, 4, 3.4 and 4.4 times greater than those of CHP in HuH7, Alexander, FCC and KNS cells, respectively, after 3 hours of incubation. All the above differences were statistically significant (p < 0.01). No statistically significant differences were seen in the case of hepatocytes. Thus, cancer cells have a common affinity with lactose CHP liposomes, however, these mechanisms appear to have no connection with the galactose-specific asialoglycoprotein receptors of hepatocytes.
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Authors | S Matsukawa, M Yamamoto, K Ichinose, N Ohata, N Ishii, T Kohji, K Akiyoshi, J Sunamoto, T Kanematsu |
Journal | Anticancer research
(Anticancer Res)
2000 Jul-Aug
Vol. 20
Issue 4
Pg. 2339-44
ISSN: 0250-7005 [Print] Greece |
PMID | 10953294
(Publication Type: Journal Article)
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Chemical References |
- Glucans
- Liposomes
- pullulan
- Inulin
- Cholesterol
- Lactose
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Topics |
- Animals
- Cholesterol
(pharmacokinetics)
- Glucans
(pharmacokinetics)
- Humans
- Inulin
(pharmacokinetics)
- Lactose
(pharmacokinetics)
- Liposomes
(pharmacokinetics)
- Liver
(metabolism)
- Liver Neoplasms
(metabolism)
- Male
- Neoplasms
(metabolism)
- Rats
- Rats, Wistar
- Tumor Cells, Cultured
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