HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

5-Fluorocytosine treatment of candidiasis on a patient receiving regular hemodialysis.

Abstract
A patient developed a severe urinary infection with Candida albicans following a cadaveric renal transplant operation. It was necessary to remove the graft and return the patient to regular hemodialysis treatment. The fungi infection was successfully eradicated by a single oral dose of 5-Fluorocytosine (20 mg/kg) after each dialysis treatment. Pharmacokinetic studies revealed that the drug had a dialyzate clearance ratio of 0.66 when compared with creatinine; the drug was not metabolized and there was no other route of elimination.
AuthorsR M Rault, B Hulme, R R Davies
JournalClinical nephrology (Clin Nephrol) Vol. 3 Issue 6 Pg. 225-7 (Jun 1975) ISSN: 0301-0430 [Print] GERMANY, WEST
PMID1095271 (Publication Type: Journal Article)
Chemical References
  • Cytosine
  • Flucytosine
Topics
  • Adult
  • Candidiasis (drug therapy)
  • Cytosine (analogs & derivatives)
  • Flucytosine (administration & dosage, metabolism, therapeutic use)
  • Humans
  • Kidney Transplantation
  • Male
  • Postoperative Complications
  • Renal Dialysis
  • Transplantation, Homologous
  • Urinary Fistula (complications)
  • Urinary Tract Infections (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: