Abstract |
A patient developed a severe urinary infection with Candida albicans following a cadaveric renal transplant operation. It was necessary to remove the graft and return the patient to regular hemodialysis treatment. The fungi infection was successfully eradicated by a single oral dose of 5-Fluorocytosine (20 mg/kg) after each dialysis treatment. Pharmacokinetic studies revealed that the drug had a dialyzate clearance ratio of 0.66 when compared with creatinine; the drug was not metabolized and there was no other route of elimination.
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Authors | R M Rault, B Hulme, R R Davies |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 3
Issue 6
Pg. 225-7
(Jun 1975)
ISSN: 0301-0430 [Print] Germany |
PMID | 1095271
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Candidiasis
(drug therapy)
- Cytosine
(analogs & derivatives)
- Flucytosine
(administration & dosage, metabolism, therapeutic use)
- Humans
- Kidney Transplantation
- Male
- Postoperative Complications
- Renal Dialysis
- Transplantation, Homologous
- Urinary Fistula
(complications)
- Urinary Tract Infections
(drug therapy)
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