5-Fluorocytosine treatment of candidiasis on a patient receiving regular hemodialysis.

A patient developed a severe urinary infection with Candida albicans following a cadaveric renal transplant operation. It was necessary to remove the graft and return the patient to regular hemodialysis treatment. The fungi infection was successfully eradicated by a single oral dose of 5-Fluorocytosine (20 mg/kg) after each dialysis treatment. Pharmacokinetic studies revealed that the drug had a dialyzate clearance ratio of 0.66 when compared with creatinine; the drug was not metabolized and there was no other route of elimination.
AuthorsR M Rault, B Hulme, R R Davies
JournalClinical nephrology (Clin Nephrol) Vol. 3 Issue 6 Pg. 225-7 (Jun 1975) ISSN: 0301-0430 [Print] GERMANY, WEST
PMID1095271 (Publication Type: Journal Article)
Chemical References
  • Cytosine
  • Flucytosine
  • Adult
  • Candidiasis (drug therapy)
  • Cytosine (analogs & derivatives)
  • Flucytosine (administration & dosage, metabolism, therapeutic use)
  • Humans
  • Kidney Transplantation
  • Male
  • Postoperative Complications
  • Renal Dialysis
  • Transplantation, Homologous
  • Urinary Fistula (complications)
  • Urinary Tract Infections (drug therapy)

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