Abstract |
1. A comparative cross-over trial of mefruside and cyclopenthiazide, each drug being given for 6 weeks, was conducted on thirty hypertensive patients with diabetes mellitus or impaired glucose tolerance. Other antihypertensive therapy, any antidiabetic therapy and potassium supplementation were kept constant throughout the trial. Dosages of mefruside and cyclopenthiazide were adjusted to give approximately equal blood pressure levels in the two drug periods. 2. There was no significant difference in the following parameters studied during the sixth week of each of the two periods of drug therapy: serum electrolytes, total CO2, chloride, urea, amylase, haemoglobin, erythrocyte sedimentation rate, platelet and white blood cell counts, lying and standing blood pressure and pulse rate, weight, fasting and 2-h glucose and insulin levels and five-value glucose and insulin curve areas, fasting calcium and phosphate. 3. Serum creatinine and uric acid showed a small but significant fall during mefruside therapy.
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Authors | H J Waal-Manning |
Journal | Clinical and experimental pharmacology & physiology
(Clin Exp Pharmacol Physiol)
1975 Mar-Apr
Vol. 2
Issue 2
Pg. 141-6
ISSN: 0305-1870 [Print] Australia |
PMID | 1095262
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Antihypertensive Agents
- Diuretics
- Electrolytes
- Sodium Chloride Symporter Inhibitors
- Sulfonamides
- Uric Acid
- Cyclopenthiazide
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Topics |
- Aged
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Blood Chemical Analysis
- Blood Pressure
(drug effects)
- Clinical Trials as Topic
- Cyclopenthiazide
(pharmacology, therapeutic use)
- Diabetes Mellitus
(blood)
- Diuretics
(pharmacology, therapeutic use)
- Electrolytes
(blood)
- Female
- Glucose Tolerance Test
- Humans
- Hypertension
(blood, drug therapy)
- Male
- Middle Aged
- Sodium Chloride Symporter Inhibitors
(pharmacology)
- Sulfonamides
- Uric Acid
(blood)
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