Second trimester levels of maternal serum inhibin A in pregnancies affected by fetal neural tube defects.

Abstract

Inhibin A is effective as a second trimester maternal serum marker for Down syndrome screening. In the present study, inhibin A levels were measured in second trimester maternal serum samples from 28 pregnancies affected with open neural tube defects; 12 associated with open spina bifida and 16 associated with anencephaly. Each measurement was expressed as a multiple of the median (MoM) for control singleton pregnancies (n=1464) of the same completed week of gestation. Inhibin A levels were not significantly altered in cases of open neural tube defects; the median value was 0.96 MoM in cases of open spina bifida and 1.19 MoM in cases of anencephaly. Therefore, second trimester maternal serum inhibin A levels will not have an impact on prenatal detection of open neural tube defects.

• Authors: G M Lambert-Messerlian, G E Palomaki, J A Canick
• Journal: Prenatal diagnosis (Prenat Diagn) Vol. 20 Issue 8 Pg. 680-2 (Aug 2000) ISSN: 0197-3851 [Print] England
• PMID: 10951483 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2000 John Wiley & Sons, Ltd.

Chemical References

• Inhibins
• Estriol

Topics

• Anencephaly (blood)
• Estriol (blood)
• Female
• Fetal Diseases (blood)
• Humans
• Inhibins (blood)
• Mosaicism
• Neural Tube Defects (blood)
• Pregnancy
• Pregnancy Trimester, Second
• Spinal Dysraphism (blood)
• Turner Syndrome (blood)