Duration of treatment for urinary tract infections in children.

Abstract

In a double-blind trial 45 children aged 6 months to 14 years with Escherichia coli infections of the urinary tract were given co-trimoxazole for two weeks and then allotted at random to one of two treatment groups for the remainder of six months; one continued with the active drug and the other with dummy tablets of identical appearance. Of the 24 children who took co-trimoxazole for two weeks and the 21 who took it for six months, 11 and 10, respectively, remained without further infections for at least a year. Over 90% of the reinfections occurred within five months of stopping the antibiotics, and the longer treatment did not cause any delay in their appearance. Thus probably a six-month course of treatment is no more likely to achieve a cure than a two-week course; nevertheless, no infection occurred during treatment, and there may be an advantage in continuing with antibiotics in small dosage.

• Authors: J M Stansfeld
• Journal: British medical journal (Br Med J) Vol. 3 Issue 5975 Pg. 65-6 (Jul 12 1975) ISSN: 0007-1447 [Print] England
• PMID: 1095132 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Placebos
• Trimethoprim
• Sulfamethoxazole

Topics

• Adolescent
• Child
• Child, Preschool
• Clinical Trials as Topic
• Drug Combinations
• Escherichia coli Infections (drug therapy)
• Female
• Humans
• Infant
• Male
• Placebos
• Recurrence
• Sulfamethoxazole (administration & dosage, therapeutic use)
• Time Factors
• Trimethoprim (administration & dosage, therapeutic use)
• Urinary Tract Infections (drug therapy)