An open-label trial of bromocriptine in nonfluent aphasia: a qualitative analysis of word storage and retrieval.

Abstract

Anomia is a commonly found in aphasia and has been attributed to a loss of representations (storage deficit) or to a loss of access to these representations (retrieval deficit). Bromocriptine, a dopamine agonist, was tested on four patients, two men and two women, with nonfluent aphasia. The patients were tested in an open-label ABBA design using a stochastic model that measured the degree of storage and retrieval deficits. All patients showed significant improvements in word retrieval. Bromocriptine may be a useful adjunct in the treatment of selected patients with a nonfluent aphasia in which retrieval deficits play a major role.

• Authors: M Gold, D VanDam, E R Silliman
• Journal: Brain and language (Brain Lang) Vol. 74 Issue 2 Pg. 141-56 (Sep 2000) ISSN: 0093-934X [Print] Netherlands
• PMID: 10950911 (Publication Type: Case Reports, Clinical Trial, Journal Article)
• Copyright: Copyright 2000 Academic Press.

Chemical References

• Dopamine Agonists
• Bromocriptine

Topics

• Aged
• Aphasia, Broca (drug therapy)
• Bromocriptine (administration & dosage, pharmacology, therapeutic use)
• Dopamine Agonists (administration & dosage, pharmacology, therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Reaction Time (drug effects)
• Verbal Behavior (drug effects)
• Vocabulary