A preliminary study on the serum protein response in canine babesiosis.

Abstract

Total serum protein, albumin, globulin, globulin fractions (alpha, beta and gamma globulins) and an acute-phase protein (alpha1-acid glycoprotein) were evaluated in dogs with naturally occurring mild (Group 1), severe (Group 2) or complicated babesiosis (Group 3). Results showed that the total serum protein, albumin, A/G ratio and alpha globulins were statistically different between Groups 1 and 2. There was no statistical difference between groups with total, beta and gamma globulins. The findings from this study suggest that dogs with mild and severe babesiosis had low total serum proteins, albumin, A/G ratio and alpha globulins; dogs with complicated babesiosis showed no typical serum protein changes or patterns; and that there was no evidence of an acute-phase response detectable on serum protein electrophoresis in any of the 3 groups. A marked acute-phase response was, however, present, as measured by the alpha1-acid glycoprotein, in all 3 groups. As this was a retrospective study, the possibility that the observed responses were due in part to concurrent disease could not be excluded.

• Authors: R G Lobetti, A J Möhr, T Dippenaar, E Myburgh
• Journal: Journal of the South African Veterinary Association (J S Afr Vet Assoc) Vol. 71 Issue 1 Pg. 38-42 (Mar 2000) ISSN: 1019-9128 [Print] South Africa
• PMID: 10949516 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Blood Proteins
• Serum Albumin
• Serum Globulins

Topics

• Acute-Phase Proteins (analysis)
• Animals
• Babesiosis (blood)
• Blood Protein Electrophoresis (veterinary)
• Blood Proteins (analysis)
• Dog Diseases (blood)
• Dogs
• Retrospective Studies
• Serum Albumin (analysis)
• Serum Globulins (analysis)
• Severity of Illness Index