Abstract |
Contrasting data are reported in the literature on the percent positivity rates (13.5%-100%) of exfoliative toxin (ET) production by S. aureus strains isolated from impetigo patients in Japan and in France. In the present study, by means of a recently available latex-test, toxin-A (ETA) or toxin-B (ETB) production was found in 67.6% of the 34 S. aureus strains isolated from 19 lesional (63.2%) and 15 non-lesional (nose or pharynx, 73.3%) areas of patients with impetigo (with no significant difference between the lesional and non-lesional isolates). ETA + ETB were produced by 44.1% of the strains, while 32.4% were non-producers. In contrast, the percent positivity rate observed in 40 [20 lesional and 20 non-lesional (nose or pharynx)] strains isolated in patients with atopic dermatitis was 15.0% (p < 0.001 both for the lesional and non-lesional strains versus impetigo, with no significant difference between lesional and non lesional strains). Finally, 26 strains from other types of specimens ( abscesses, hemocultures, urine, central venous catheters, bronchoalveolar lavages) showed an 11.5% production rate of ETA or ETB (p < 0.001 versus impetigo strains, no significance versus atopic dermatitis). These data point to a significant association between exfoliative toxin production and S. aureus strains isolated in impetigo, both in lesional areas and in nasal/pharyngeal reservoirs. An attempt to correlate SmaI pulsed-field gel electrophoresis (PFGE) restriction patterns and exfoliative toxin production showed no significant association in either group.
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Authors | E Capoluongo, A Giglio, M Belardi, F Leonetti, A Frasca, A Giannetti, F Ameglio |
Journal | The new microbiologica
(New Microbiol)
Vol. 23
Issue 1
Pg. 21-7
(Jan 2000)
ISSN: 1121-7138 [Print] Italy |
PMID | 10946402
(Publication Type: Journal Article)
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Chemical References |
- Exfoliatins
- CCCGGG-specific type II deoxyribonucleases
- Deoxyribonucleases, Type II Site-Specific
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Topics |
- Adolescent
- Adult
- Aged
- Bacterial Typing Techniques
- Child
- Child, Preschool
- Deoxyribonucleases, Type II Site-Specific
(metabolism)
- Dermatitis, Atopic
(microbiology)
- Electrophoresis, Gel, Pulsed-Field
- Exfoliatins
(metabolism)
- Female
- Humans
- Impetigo
(microbiology)
- Infant
- Male
- Middle Aged
- Nose
(microbiology)
- Pharynx
(microbiology)
- Staphylococcal Infections
(microbiology)
- Staphylococcus aureus
(classification, genetics, isolation & purification, metabolism)
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