Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26.

Abstract

Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at theta = 0 for markers DXS425, DXS1254, DXS1114, and HPRT.

• Authors: R Caspari, S Uhlhaas, W Friedl, M Knapp, P Propping
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 93 Issue 4 Pg. 290-3 (Aug 14 2000) ISSN: 0148-7299 [Print] United States
• PMID: 10946355 (Publication Type: Journal Article)

Chemical References

• Genetic Markers

Topics

• Genetic Linkage
• Genetic Markers
• Humans
• Intellectual Disability (genetics)
• Lod Score
• Male
• Pedigree
• Trinucleotide Repeats
• X Chromosome