Retinoids and renal development.

Although it has long been appreciated that retinoids play an essential role in kidney organogenesis, it has only recently been recognized that even mild fetal vitamin A deficiency syndromes can result in a reduction in nephron number. Recent studies have also begun to define the cellular and molecular events associated with retinoid actions in the fetal kidney and have demonstrated the essential function of retinoids in branching growth of the ureteric bud. Importantly, characterization of the renal developmental effects of RAR alpha/beta 2 double homozygous mice combined with metanephric organ culture studies have together shown that one essential function of retinoid action in the developing kidney is the maintenance of c-ret expression in the tips of the ureteric bud. However, many other potential retinoid target genes including midkine, sonic hedgehog, Hox d-11, matrix metalloproteinases, and tissue inhibitors of metalloproteinases appear to play important roles in renal development and might be important downstream mediators of retinoid effects in the developing kidney. It can, therefore, be anticipated that important new insights into fetal kidney development will be forthcoming in the near future, as the essential target genes affected by retinoid signal transduction are progressively elucidated.
AuthorsC R Burrow
JournalExperimental nephrology (Exp Nephrol) 2000 Jul-Oct Vol. 8 Issue 4-5 Pg. 219-25 ISSN: 1018-7782 [Print] SWITZERLAND
PMID10940720 (Publication Type: Journal Article, Review)
CopyrightCopyright 2000 S. Karger AG, Basel
Chemical References
  • Drosophila Proteins
  • Proto-Oncogene Proteins
  • Receptors, Retinoic Acid
  • Retinoids
  • Tretinoin
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret oncogene protein, Drosophila
  • Animals
  • Drosophila Proteins
  • Humans
  • Kidney (embryology, growth & development)
  • Kidney Diseases (etiology)
  • Proto-Oncogene Proteins (genetics)
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases (genetics)
  • Receptors, Retinoic Acid (genetics, physiology)
  • Retinoids
  • Tretinoin (physiology)
  • Vitamin A Deficiency (complications)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: