Risperidone in idiopathic and symptomatic dystonia: preliminary experience.

Abstract

Risperidone is a heterocyclic neuroleptic with prominent antiserotoninergic (5HT2) as well as antidopaminergic (D2) activity. We studied the efficacy of risperidone in the treatment of idiopathic and symptomatic dystonias in seven patients using the Fahn and Marsden rating scale for torsion dystonia before and after four weeks of treatment (2-6 mg/day). The twisting and involuntary movements with abnormal postures decreased in all the patients treated, with a statistically significant mean improvement (41%; p = 0.009, CI 95%). Our results suggest that risperidone is useful in idiopathic and symptomatic dystonia.

• Authors: E Grassi, S Latorraca, S Piacentini, P Marini, S Sorbi
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 21 Issue 2 Pg. 121-3 (Apr 2000) ISSN: 1590-1874 [Print] Italy
• PMID: 10938193 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dopamine Antagonists
• Hypnotics and Sedatives
• Serotonin Antagonists
• Risperidone

Topics

• Adolescent
• Adult
• Dopamine Antagonists (adverse effects, therapeutic use)
• Dystonia (drug therapy, physiopathology)
• Humans
• Hypnotics and Sedatives
• Male
• Middle Aged
• Risperidone (adverse effects, therapeutic use)
• Serotonin Antagonists (therapeutic use)
• Treatment Outcome