Abstract |
We report the previously undescribed occurrence of extramedullary blast crisis in a patient with chronic myelogenous leukemia in complete cytogenetic and molecular remission on interferon-alpha. Development of bilateral testicular swelling prompted a biopsy showing stromal infiltration with CD20 and TdT positive immature cells. On repeated examinations, the bone marrow remained BCR/ABL negative by RT-PCR analysis. However, the cerebrospinal fluid (CSF) contained atypical lymphocytes positive for the P210 BCR-ABL product. Following treatment with testicular irradiation, intrathecal methotrexate, systemic chemotherapy and an unrelated donor transplant, the patient showed no evidence of disease until 9 months post-transplant, when he relapsed in lymphoid blast crisis in both bone marrow and CSF.
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Authors | A Beedassy, D Topolsky, M Styler, P Crilley |
Journal | Leukemia research
(Leuk Res)
Vol. 24
Issue 8
Pg. 733-5
(Aug 2000)
ISSN: 0145-2126 [Print] England |
PMID | 10936425
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Interferon-alpha
- Fusion Proteins, bcr-abl
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Topics |
- Adult
- Antineoplastic Agents
(therapeutic use)
- Blast Crisis
- Fusion Proteins, bcr-abl
(genetics)
- Genes, abl
- Humans
- Interferon-alpha
(therapeutic use)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
(drug therapy, genetics, pathology)
- Male
- Remission Induction
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