[Effects of bromantane and sidnocarb on long-term operant conditioning and its vegetative correlates in rats].

Abstract

Bromantan (20 mg/kg, p.o.) and sydnocarb (10 mg/kg, p.o.) augment the efficacy of a 5-h operant activity in rats, the effect being achieved through different pathways. Sydnocarb increases the number of operant reactions and exhausts the sympathico adrenal system reserves. Bromantan favors the activity optimization by reducing the number of errors at a smaller number of operant reactions. Bromantan increases the tension of motivational component (electric pain irritation avoidance), whereas sydnocarb decreases this component of the operant behavior. None of the two drugs affects the degree of functional activation of the cardiovascular system.

• Authors: I S Morozov, L P Efimova, Iu A Salenko
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2000 May-Jun Vol. 63 Issue 3 Pg. 11-5 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie bromantana i sidnokarba na éffektivnost' dlitel'noĭ operantnoĭ deiatel'nosti i ee vegetativnye korreliaty u krys.
• PMID: 10934588 (Publication Type: Journal Article)

Chemical References

• Catecholamines
• Central Nervous System Stimulants
• Psychotropic Drugs
• Sydnones
• Dihydroxyphenylalanine
• Amantadine
• bromantane
• sidnocarb
• Dopamine

Topics

• Amantadine (analogs & derivatives, pharmacology)
• Animals
• Avoidance Learning (drug effects)
• Catecholamines (urine)
• Central Nervous System Stimulants (pharmacology)
• Conditioning, Operant (drug effects)
• Dihydroxyphenylalanine (urine)
• Dopamine (urine)
• Heart Rate (drug effects)
• Male
• Psychotropic Drugs (pharmacology)
• Rats
• Sydnones (pharmacology)
• Sympathetic Nervous System (drug effects)
• Time