Abstract | OBJECTIVE: This study was conducted to assess the usefulness of dimeric inhibin A as a fourth marker for Down's syndrome screening in addition to AFP, hCG and uE3 markers for native Japanese women. METHODS: Serum specimens from 367 native Japanese women in the second trimester were assayed for dimeric inhibin A levels. Day specific dimeric inhibin A medians were established for gestational ages 15.0-21.9. Weekly median values for the native Japanese were compared with those of a U.S. population. Selected Japanese specimens from 15 diagnosed Down's syndrome and 3 trisomy 18 cases were also assayed for dimeric inhibin A. RESULTS: Dimeric inhibin A levels did not vary greatly over the gestational age range as expected. Median value comparison showed that native Japanese dimeric inhibin A medians are higher than the U.S. population medians by an average of 7.95%. Native Japanese dimeric inhibin A median values in this study are 1.77 times higher in Down's syndrome cases than in unaffected pregnancies. Trisomy 18 dimeric inhibin A levels show no significant difference from the unaffected pregnancies. CONCLUSIONS: This report shows for the first time that dimeric inhibin A can be informative as a fourth marker for Down's syndrome screening in native Japanese women. We expect the addition of dimeric inhibin A to a triple marker protocol will increase the accuracy of predicted risk for all pregnancies screened and increase the detection rate of Down's syndrome affected pregnancies.
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Authors | K Yoshida, Y Kuwabara, T Tanaka, T Onda, R Kudo, H Yamamoto, A Sato, K Yanagida, T Okai, M Sakai, Y Takai, H Uemura, K Hoshi, Y Fukada, T Aono, K Maeda, S Ogita, O Ishiko, Y Murata, T Kanzaki, F Myrick, R E Grier |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 26
Issue 3
Pg. 171-4
(Jun 2000)
ISSN: 1341-8076 [Print] Australia |
PMID | 10932977
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Chorionic Gonadotropin
- alpha-Fetoproteins
- Inhibins
- Estriol
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Topics |
- Biomarkers
(blood)
- Chorionic Gonadotropin
(blood)
- Chromosomes, Human, Pair 18
- Dimerization
- Down Syndrome
(blood, diagnosis)
- Estriol
(blood)
- Female
- Gestational Age
- Humans
- Inhibins
(blood)
- Japan
- Maternal Age
- Pregnancy
- Pregnancy, High-Risk
- Prenatal Diagnosis
- Trisomy
- alpha-Fetoproteins
(analysis)
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