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Dimeric inhibin A as a fourth marker for Down's syndrome maternal serum screening in native Japanese women.

AbstractOBJECTIVE:
This study was conducted to assess the usefulness of dimeric inhibin A as a fourth marker for Down's syndrome screening in addition to AFP, hCG and uE3 markers for native Japanese women.
METHODS:
Serum specimens from 367 native Japanese women in the second trimester were assayed for dimeric inhibin A levels. Day specific dimeric inhibin A medians were established for gestational ages 15.0-21.9. Weekly median values for the native Japanese were compared with those of a U.S. population. Selected Japanese specimens from 15 diagnosed Down's syndrome and 3 trisomy 18 cases were also assayed for dimeric inhibin A.
RESULTS:
Dimeric inhibin A levels did not vary greatly over the gestational age range as expected. Median value comparison showed that native Japanese dimeric inhibin A medians are higher than the U.S. population medians by an average of 7.95%. Native Japanese dimeric inhibin A median values in this study are 1.77 times higher in Down's syndrome cases than in unaffected pregnancies. Trisomy 18 dimeric inhibin A levels show no significant difference from the unaffected pregnancies.
CONCLUSIONS:
This report shows for the first time that dimeric inhibin A can be informative as a fourth marker for Down's syndrome screening in native Japanese women. We expect the addition of dimeric inhibin A to a triple marker protocol will increase the accuracy of predicted risk for all pregnancies screened and increase the detection rate of Down's syndrome affected pregnancies.
AuthorsK Yoshida, Y Kuwabara, T Tanaka, T Onda, R Kudo, H Yamamoto, A Sato, K Yanagida, T Okai, M Sakai, Y Takai, H Uemura, K Hoshi, Y Fukada, T Aono, K Maeda, S Ogita, O Ishiko, Y Murata, T Kanzaki, F Myrick, R E Grier
JournalThe journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 26 Issue 3 Pg. 171-4 (Jun 2000) ISSN: 1341-8076 [Print] Australia
PMID10932977 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Chorionic Gonadotropin
  • alpha-Fetoproteins
  • Inhibins
  • Estriol
Topics
  • Biomarkers (blood)
  • Chorionic Gonadotropin (blood)
  • Chromosomes, Human, Pair 18
  • Dimerization
  • Down Syndrome (blood, diagnosis)
  • Estriol (blood)
  • Female
  • Gestational Age
  • Humans
  • Inhibins (blood)
  • Japan
  • Maternal Age
  • Pregnancy
  • Pregnancy, High-Risk
  • Prenatal Diagnosis
  • Trisomy
  • alpha-Fetoproteins (analysis)

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