[Topical treatment of peri-implantitis with metronidazole dental gel 25%. Clinical analysis and microbiological control].

Abstract

BACKGROUND:

Aim of this research is to verify the efficacy of metronidazole dental gel 25%, used as a topical antibiotic for the treatment of peri-implantitis. The efficacy of the medicine in the starting phase of the disease (mucositis), as well as during peri-implantitis involving bone-bearing loss has been evaluated.

METHODS:

Twenty patients were chosen as a sample for the study. After careful evaluation of the several protocols concerning peri-implantitis treatment, some diagnostic clinical parameters have been recorded for each patient and metronidazole dental gel 25% (Elyzol Cabon) has been administered in two applications at perimplants pocket (one after a week). For each patient 3 microbiological drawings were made for the evaluation of the bacterial population around the implant site.

RESULTS:

From the microbiological examination a decrease of Gram- and an increase of Gram+ which returned in almost all the patients to normal levels have been observed; moreover, in all the patients a gradual decrease of PMN, resolution index of the inflammatory process was obtained, confirmed also by a remarkable improvement of all the observed diagnostic parameters, except for the peri-implants bone radiotransparency which was unchanged.

CONCLUSIONS:

The research showed that the peri-implant diseases can be positively resolved by using the metronidazole dental gel 25% topical antibiotic. This drug led to a 60-70% decrease of Gram-, and 40-50% increase for Gram+, bringing these back to normal values in almost all the patients. Moreover, a good recovery of the peri-implants soft tissues has been observed.

• Authors: E Stellini, A Migliorato, S Mazzoleni, A Mottola, L Lombardi, G A Favero
• Journal: Minerva stomatologica (Minerva Stomatol) 2000 Jan-Feb Vol. 49 Issue 1-2 Pg. 59-67 ISSN: 0026-4970 [Print] Italy
• Vernacular Title: Trattamento topico delle perimplantiti con metronidazolo gel dentale 25%. Analisi clinica e controllo microbiologico.
• PMID: 10932909 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Dental Implants
• Gels
• Metronidazole

Topics

• Administration, Topical
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Bacteria (isolation & purification)
• Dental Implants (adverse effects)
• Evaluation Studies as Topic
• Female
• Gels
• Humans
• Male
• Metronidazole (administration & dosage)
• Middle Aged
• Mouth (microbiology)
• Periodontitis (etiology, prevention & control)
• Prosthesis-Related Infections (diagnosis, drug therapy)
• Time Factors