| Abstract | Cultivated keratinocytes have been used for treatment of chronic wounds. Our group developed a new application form, using a suspension of subconfluently cultivated keratinocytes in fibrin glue (keratinocyte-fibrin-glue-suspension = KFGS), which has successfully been used in burn patients. Altogether 8 patients (average: 57 yrs.) with complex chronic wounds of different origin were treated with KFGS. All wounds, which had been existing from 4 months to 14 years, showed good reepithelization. Up to now there has been observed stable wound closure for 4 years after grafting. This study demonstrates the wound healing potency of a keratinocyte-fibrin-glue-suspension also for chronic wounds. Fibrin glue seems to be both an ideal application vehicle as a biological matrix for the cultivated keratinocytes. The transplantation of cultivated autologous keratinocytes as suspension in fibrin glue is a promising way in the treatment of chronic wounds. |
| Authors | H Bannasch, R E Horch, E Tánczos, G B Stark
(Affiliation: Abteilung Plastische und Handchirurgie, Chirurgische Universitätsklinik Freiburg. bannasch at ch11.ukl.uni-freiburg.de)
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| Journal | Zentralblatt für Chirurgie
(Zentralbl Chir)
Vol. 125 Suppl 1
Pg. 79-81
( 2000)
ISSN: 0044-409X GERMANY |
| Vernacular Title | Behandlung chronischer Wunden mit kultivierten autologen Keratinozyten als Suspension in Fibrinkleber. |
| PMID | 10929653
(Publication Type: English Abstract, Journal Article)
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| Chemical References |
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| Topics |
- Adult
- Aged
- Aged, 80 and over
- Animals
- Cells, Cultured
- Chronic Disease
- Debridement
- Female
- Fibrin Tissue Adhesive
(administration & dosage)
- Follow-Up Studies
- Humans
- Keratinocytes
(cytology, transplantation)
- Male
- Mice
- Mice, Nude
- Middle Aged
- Time Factors
- Transplantation, Autologous
- Wound Healing
- Wounds and Injuries
(surgery)
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