Abstract | OBJECTIVE: CASE SUMMARY: A 73-year-old white woman was admitted for the treatment of metastatic breast carcinoma with an experimental oral paclitaxel solution in combination with cyclosporine capsules. After ingestion of the cyclosporine capsules, the patient collapsed within one hour. She initially experienced severe hypotension and bradycardia. After a few minutes, she developed severe tachycardia, dyspnea, and decreased consciousness. Administration of epinephrine, dexamethasone, clemastine, oxygen, and gelofusine ( succinylated gelatin 4% in NaCl 0.9%) infusion resulted in complete recovery after several hours. The planned oral paclitaxel administration was canceled. Intravenous paclitaxel was given the next day, preceded by standard premedication with dexamethasone, clemastine, and cimetidine, without complications. DISCUSSION: CONCLUSIONS:
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Authors | R A Kuiper, M M Malingré, J H Beijnen, J H Schellens |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
2000 Jul-Aug
Vol. 34
Issue 7-8
Pg. 858-61
ISSN: 1060-0280 [Print] United States |
PMID | 10928395
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Surface-Active Agents
- cremophor EL
- Cyclosporine
- Paclitaxel
- Glycerol
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Topics |
- Administration, Oral
- Aged
- Anaphylaxis
(chemically induced)
- Breast Neoplasms
(drug therapy)
- Cyclosporine
(adverse effects, therapeutic use)
- Drug Therapy, Combination
- Female
- Glycerol
(adverse effects, analogs & derivatives)
- Humans
- Paclitaxel
(therapeutic use)
- Surface-Active Agents
(adverse effects)
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