Abstract | RATIONALE: OBJECTIVES: The present study explored possible reversal by ganaxolone and related neuroactive steroids of some behavioral effects of additional pharmacological challenges. METHODS: Direct behavioral observation and photocell-counted locomotor activity of male, Swiss-Webster mice were made with various compounds alone and in conjunction with ganaxolone. RESULTS: CONCLUSIONS: The present findings support the unique pharmacological effects of neuroactive steroids as a novel class of positive allosteric modulators of GABA.
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Authors | J T Ungard, M Beekman, M Gasior, R B Carter, D Dijkstra, J M Witkin |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 148
Issue 4
Pg. 336-43
(Mar 2000)
ISSN: 0033-3158 [Print] Germany |
PMID | 10928304
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticonvulsants
- Central Nervous System Stimulants
- Convulsants
- Dopamine Uptake Inhibitors
- Psychotropic Drugs
- Steroids
- gamma-Aminobutyric Acid
- Pregnenolone
- ganaxolone
- Pregnanolone
- Cocaine
- Pentylenetetrazole
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Topics |
- Animals
- Anticonvulsants
(pharmacology)
- Behavior, Animal
(drug effects)
- Central Nervous System Stimulants
(antagonists & inhibitors, pharmacology)
- Cocaine
(antagonists & inhibitors, pharmacology)
- Convulsants
(pharmacology)
- Dopamine Uptake Inhibitors
(antagonists & inhibitors, pharmacology)
- Dose-Response Relationship, Drug
- Male
- Mice
- Motor Activity
(drug effects)
- Pentylenetetrazole
(antagonists & inhibitors, pharmacology)
- Pregnanolone
(analogs & derivatives, pharmacology)
- Pregnenolone
(pharmacology)
- Psychotropic Drugs
(antagonists & inhibitors, pharmacology)
- Steroids
(pharmacology)
- Synaptic Transmission
(drug effects)
- gamma-Aminobutyric Acid
(physiology)
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