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Update: expanded availability of thimerosal preservative-free hepatitis B vaccine.

Abstract
Thimerosal, a mercury-based compound, is no longer used as a preservative in any of the pediatric hepatitis B vaccines licensed in the United States. On March 28, 2000, SmithKline Beecham Biologicals (Rixensart, Belgium) received approval from the Food and Drug Administration of a supplement to its hepatitis B license to include the manufacture of single-antigen, preservative-free hepatitis B vaccine (Engerix-B, pediatric/adolescent); distribution of this product has begun. A single-antigen, preservative-free hepatitis B vaccine (Recombivax HB, pediatric) from Merck Vaccine Division (West Point, Pennsylvania) had earlier received similar approval (1). A preservative-free Haemophilus influenzae type b (Hib)/hepatitis B combination vaccine (Comvax) from Merck Vaccine Division also is available. An adequate supply of preservative-free hepatitis B vaccine is available for all infant and childhood vaccinations. Thimerosal preservative-containing hepatitis B vaccines may continue to be used for vaccination of adolescents and adults as recommended (2).
AuthorsCenters for Disease Control and Prevention (CDC)
JournalMMWR. Morbidity and mortality weekly report (MMWR Morb Mortal Wkly Rep) Vol. 49 Issue 28 Pg. 642, 651 (Jul 21 2000) ISSN: 0149-2195 [Print] United States
PMID10926308 (Publication Type: Journal Article)
Chemical References
  • Hepatitis B Vaccines
  • Preservatives, Pharmaceutical
  • Thimerosal
Topics
  • Hepatitis B Vaccines (supply & distribution)
  • Humans
  • Infant, Newborn
  • Preservatives, Pharmaceutical
  • Thimerosal
  • United States

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