Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.

Abstract

The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Cki delta was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and "skein"-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for Cki delta in the abnormal processing of tau.

• Authors: C Schwab, A J DeMaggio, N Ghoshal, L I Binder, J Kuret, P L McGeer
• Journal: Neurobiology of aging (Neurobiol Aging) 2000 Jul-Aug Vol. 21 Issue 4 Pg. 503-10 ISSN: 0197-4580 [Print] United States
• PMID: 10924763 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• tau Proteins
• Protein Kinases
• Casein Kinases

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (metabolism, pathology)
• Amyotrophic Lateral Sclerosis (metabolism, pathology)
• Antibody Specificity
• Brain (enzymology, pathology)
• Casein Kinases
• Female
• Humans
• Immunohistochemistry
• Inclusion Bodies (chemistry, enzymology)
• Lewy Bodies (chemistry, enzymology)
• Male
• Middle Aged
• Neurodegenerative Diseases (metabolism, pathology)
• Neurofibrillary Tangles (chemistry, enzymology)
• Neuroglia (chemistry, enzymology)
• Parkinson Disease (metabolism, pathology)
• Protein Kinases (analysis, immunology, metabolism)
• tau Proteins (analysis, immunology, metabolism)